NMR Problem Solving.
How to solve a nmr problem with dept and other nmr data
Solving an NMR problem with DEPT and other NMR data involves several steps, including the analysis of the spectrum, determination of chemical shifts, integration of peaks, and correlation with other spectra. Here is a general approach that can be followed:
Analyze the spectrum: First, examine the DEPT spectrum to determine the number of signals and whether they represent CH, CH2, or CH3 groups. In DEPT, CH and CH3 groups will produce positive peaks, while CH2 groups will produce negative peaks.
Determine chemical shifts: Next, determine the chemical shifts of the signals in the DEPT spectrum. Compare the chemical shifts with reference data to identify the functional groups and their position in the molecule.
Integrate peaks: Use integration to determine the relative number of protons in each functional group. This can be done by integrating the peak areas in the DEPT spectrum.
Correlate with other spectra: Finally, correlate the information from the DEPT spectrum with other NMR spectra, such as the proton NMR spectrum, carbon NMR spectrum, and COSY spectrum. This will help to confirm the assignments made based on the DEPT spectrum and provide additional information about the molecule’s structure.
Overall, solving an NMR problem with DEPT and other NMR data requires a good understanding of NMR spectroscopy and the ability to interpret complex spectra. It may be helpful to consult with a more experienced NMR spectroscopy pist or reference texts to ensure accurate interpretation of the data.